||Principally ZDV and PIs (such as LPV/r, RTV) but can occur with all ARVs
- Nausea, emesis—may be associated with anorexia and/or abdominal pain
|Varies with ARV agent;10%–30% in some series.
||Instruct patient to take PIs with food.
Generally improves with time; monitor for weight loss, ARV adherence.
|Reassure patient/caretaker that nausea and vomiting will likely decrease over time.
Provide supportive care including instruction on dietary modification.
Although antiemetics are not generally indicated, they may be useful in extreme or persistent cases.
||PIs (NFV, LPV/r, FPV/r), buffered ddI
- Generally soft, more frequent stools
|Varies with ARV agent;
10%–30% in some series.
||Generally improves with time (usually over 6-8 weeks); monitor for weight loss, dehydration.
||Exclude infectious causes of diarrhea.
Although data in children on treatment for ARV-associated diarrhea are lacking, dietary modification, use of calcium carbonate, bulk-forming agents (psyllium), or antimotility agents (loperamide) may be helpful.
While there are few published data on its use, crofelemer is FDA-approved for treatment of ART-associated diarrhea in adults but not in children.
||ddI, d4T (especially concurrently or with TDF), boosted PIs.
Reported, albeit rarely, with most ARVs.
- Any time, usually after months on therapy
- Emesis, abdominal pain, elevated amylase and lipase (asymptomatic hyperamylasemia or elevated lipase do not in and of themselves indicate pancreatitis).
|<1%–2% in recent series.
Frequency was higher in the past with higher dosing of ddI.
|Concomitant treatment with other medications associated with pancreatitis (e.g., TMP-SMX, pentamidine, ribavirin).
Previous episode of pancreatitis.
|Avoid use of ddI in patients with history of pancreatitis.
||Discontinue offending agent–avoid reintroduction.
Manage symptoms of acute episode.
If associated with hypertriglyceridemia, consider interventions to lower TG levels.