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Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents

Tables

Table 3. Recommended Doses of First-Line Drugs for Treatment of Tuberculosis in Adults and Adolescents

(Last updated:5/7/2013; last reviewed:5/7/2013)

 

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Table 3. Recommended Doses of First-Line Drugs for Treatment of Tuberculosis in Adults and Adolescents
Drug Daily 3x/week
Isoniazid
5 mg/kg (usual dose 300 mg)
15 mg/kg (usual dose 900 mg)
Rifampin

Note: Rifampin is not recommended in patients receiving HIV PIs, ETR, RPV, or EVG/COBI/TDF/FTC
10 mg/kg (usual dose 600 mg) 10 mg/kg (usual dose 600 mg)
Rifabutin
without HIV PIs, EFV, RPV, or EVG/COBI/TDF/FTC
5 mg/kg (usual dose 300 mg)
5 mg/kg (usual dose 300 mg)
with HIV PIs
150 mga
300 mga
with EFV
450–600 mg
450–600 mg
with EVG/COBI/TDF/FTC
150 mgb
150 mgb
Pyrazinamide
(weight-based dosing)


40–55 kg 1000 mg (18.2–25.0 mg/kg ) 1500 mg (27.3–37.5 mg/kg)
56–75 kg
1500 mg (20.0–26.8 mg/kg)
2500 mg (33.3–44.6 mg/kg)
76-90 kg
2000 mg (22.2–26.3 mg/kg)
3000 mg (33.3–39.5 mg/kg)
>90 kg
2000 mgc
3000 mgc
Ethambutol
(weight-based dosing)


40–55 kg 800 mg (14.5–20.0 mg/kg) 1200 mg (21.8–30.0 mg/kg)
56–75 kg
1200 mg (16.0–21.4 mg/kg)
2000 mg (26.7–35.7 mg/kg)
76-90 kg
1600 mg (17.8–21.1 mg/kg)
2400 mg (26.7–31.6 mg/kg)
>90 kg
1600 mgc
2400 mgc
a Acquired rifamycin resistance has been reported in patients with inadequate rifabutin levels while on 150 mg twice weekly dosing together with ritonavir-boosted PIs. May consider therapeutic drug monitoring when rifabutin is used with a ritonavir-boosted PI and adjust dose accordingly.
b Avoid co-administration of EVG/COBI/TDF/FTC with rifabutin, if possible. If used together, consider therapeutic drug monitoring and adjust dose accordingly.
c Monitor for therapeutic response and consider therapeutic drug monitoring to assure dosage adequacy in patients who weigh >90 kg.

Key to Acronyms: COBI = cobicistat; EFV = efavirenz; EVG = elvitegravir; FTC = emtricitabine; MVC = maraviroc; NNRTI = non-nucleoside reverse transcriptase inhibitor; PI = protease inhibitor; TDF = tenofovir disoproxil fumarate